MG is a chronic autoimmune, neuromuscular disease that leads to fluctuating muscle weakness and abnormally fatigued muscles. Muscle weakness is caused by circulating antibodies that block acetylcholine receptors at the neuromuscular junction.
Typical symptoms of MG are: Muscle power that declines with exercise and increases after rest. Muscle weakness varies between days and is also worse at the end of the day. Muscular strength is initially normal or nearly normal, but subsequently decreases as the patient uses the muscles.
The disease is rare but occurs in all ages, and most commonly affects women between 20 and 40 years of age and men over 50 years of age. Two-thirds of patients with myasthenia gravis are women. Today, the prognosis with treatment is good.
Myasthenia Gravis is treated medically with acetylcholinesterase inhibitors or immunosuppressants, and, in selected cases, thymectomy.
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